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A dose-dependent reduction in hearing threshold shifts was obtained in rats after continuous treatment with HK-2 for 5 days prior to noise exposure, and this protection lasted for 10 days postexposure [156]

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Abbreviations 12MP+6MHP: 12-peptide vaccine plus melanoma-specific helper peptides 4-1BB: CD137 A2AR: Adenosine A2A Receptor AE: Adverse Events ATT: Adoptive T-cell transfer B7-H3: B7 Homolog 3 BRAF: B-Raf proto-oncogene CAR: Chimeric Antigen Receptor CB: Cord Blood CCR: Chemokine Receptor CID: Chemical Inducer of Dimerization CIML: Cytokine-induced memory-like CISH: Cytokine-inducible SH2-containing protein CISHKO: CISH knockout CNS: Central Nervous System CR: Complete Responses CRS: Cytokine Release Syndrome CSPG4: Chondroitin Sulfate Proteoglycan 4 CTL: Cytotoxic T cells CTLA-4: Cytotoxic T-Lymphocyte-Associated Protein 4 CXCR: C-X-C Chemokine Receptor DCV: Dendritic-cell-based Vaccination DNAM-1: DNAX Accessory Molecule-1 DTH: Delayed-type Hypersensitivity ELISPOT: Enzyme-Linked Immunospot FACS: Fluorescence-Activated Cell Sorting FDA: Food and Drug Administration GD2: Disialoganglioside GM-CSF: Granulocyte-Macrophage Colony-Stimulating Factor GMP: Good Manufacturing Practice HER2: Human epidermal growth factor receptor 2 HLA: Human Leukocyte Antigen ICANS: Immune-effector Cell-Associated Neurotoxicity ICI: Immune Checkpoint Inhibition IDO: 3-Idolamine-Dioxygenase IFN-: Interferon- IL-4: Interleukin-4 IL13R2: Interleukin-13 receptor alpha 2 JAK-STAT: Janus kinase-signal transducer and activator of transcription KIR: Killer-Cell Immunoglobulin-like Receptor LAG-3: Lymphocyte-Activation Gene 3 MACS: Magnetic-Activated Cell Sorting MAGE: Melanoma Antigen Gene MAPK: Mitogen-Activated Protein Kinase MART-1: Melanoma Antigen Recognized by T cells 1 MEK: Mitogen-activated protein kinase MICA: induced self-ligands including HLA class I chain-related protein A MICB: HLA class I chain-related protein B MRI: Magnetic Resonance Imaging NK: Natural Killer NRAS: Neuroblastoma RAS viral oncogene homolog NY-ESO-1: New York Esophageal Squamous Cell Carcinoma 1 ORR: Objective Response Rates FoxP3: Forkhead box P3 PD-1: Programmed Cell Death Protein 1 PD-L1: Programmed Death Ligand 1 PFS: Progression-Free Survival PGE2: Prostaglandin E2 PR: Partial Responses PRAME: Preferentially Expressed Antigen in Melanoma TCR: T-Cell Receptor TCR-T: T-Cell Receptor-engineered T cells TH1: T helper type 1 TIGIT: T cell immunoreceptor with Ig and ITIM domains TIL: Tumor-Infiltrating Lymphocyte TIME: Tumor Microenvironment TLR: Toll-Like Receptor TNF-: Tumor Necrosis Factor TRAIL: TNF-Related Apoptosis-Inducing Ligand TYRP1: Tyrosinase-Related Rrotein 1 ULBP: UL16-Binding Protein UV: Ultraviolet References Ferlay J, Ervik M, Lam F, Laversanne M, Colombet M, Mery L, Pieros M, Znaor A, Soerjomataram I, Bray F

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